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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
In addition to transpilers, you can look into embedded Python runtimes. PyPy.js technically allows you to run Python code from JavaScript, though this specific project hasn't seen much activity for a few years.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.