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swifter
A package which efficiently applies any function to a pandas dataframe or series in the fastest available manner (by jmcarpenter2)
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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
Since you already have a working python script, you can try swifter with minimal effort to see if it brings about a significant speedup before digging further.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.