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JUCE
JUCE is an open-source cross-platform C++ application framework for desktop and mobile applications, including VST, VST3, AU, AUv3, LV2 and AAX audio plug-ins.
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There are free (as far as licensing goes) alternatives such as DPF, but you will be doing a lot more of your own legwork with this system as not as much is provided for you.
For frameworks, JUCE is the most popular, and probably one you can find the most information on.
There are also up-and-coming languages like SOUL which can be transformed into plugins in their own right.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.