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WASM has its moments, as you can see in this[1] benchmark it outperforms JS and native addons on certain tasks.
Since the bottleneck with native addons is usually data copying/marshalling, and we have direct access to WebAssembly memory from the JavaScript side, using WebAssembly on this "shared" memory might become the best approach for computationally heavy tasks. I wrote about it a bit here[2].
[1] https://github.com/zandaqo/iswasmfast
Yup! We do a Typescript/Node.js/GraphQL back-end with React/Relay/Typescript on the front end.
https://github.com/coralproject/talk
It's pretty nice having the whole code base share types, syntax, structure, etc.