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perfect6502
perfect6502, a MOS 6502 CPU emulator that performs a simulation of the original NMOS 6502 netlist
Some other instruction sets in some JSON: https://github.com/asmjit/asmjit/tree/master/db
Likely useful: https://github.com/mist64/perfect6502 and http://www.visual6502.org/. These are transistor-level simulations based on die shots. From these you can derive the cycle times of each instruction with 100% confidence.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.