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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
Quassel - https://www.quassel-irc.org/ - looks like a contender and it supports MacOS, Srain (https://srain.silverrainz.me/) also has a more modern appearance and is built for GTK3 but I don't see official macOS builds available.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.