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InfluxDB
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> Another problem is that there are hundreds of built-in library functions that need to be compiled from Python from C
An approach I've advocated as one of the main authors of py2many is that all of the python builtin functions be written in a subset of python[1] and then compiled into native code. This has the benefit of avoiding GIL, problems with C-API among other things.
Do checkout the examples here[2] which work out of the box for many of the 8-9 supported backends.
[1] https://github.com/py2many/py2many/blob/main/doc/langspec.md
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