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libdatachannel
C/C++ WebRTC network library featuring Data Channels, Media Transport, and WebSockets
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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
You can use Native Messaging. See NativeMessagingHosts.
I've successfully used libdatachannel to Web pages to connect native applications and stream data to the browser.
Using an extension we can create an offscreen document, connect to a Native Messaging host, stream stdin to a local application, and stream stdout to the browser (Web page), see offscreen-webrtc.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.