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When using python with sql databases like postgres or mariadb or SQLite you would use SQLAlchemy or another ORM of if you're feeling brave, you code it by hand. With ORMs you provide the address of your database and it connects for you, letting you use abstractions instead of writing all the SQL yourself (kind of analogous to using vlookups or index match instead of manually entering data).
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Hence, a higher number means a more popular project.