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Then there is the question of connecting to the user's crypto wallet in order to sign blockchain transactions. For a C# application this is achieved via the C# Wallet Connect (WalletConnectSharp)
There are also decentralized network services like The Graph or Pocket Network that provide decentralized access to Ethereum and other blockchain networks. Note that these services primarily provide APIs for querying blockchain data, and may not provide full functionality for sending transactions or executing smart contracts like a full Ethereum node or services like Infura and Alchemy.