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For me, the major thing is training noobs on how to setup a python env and how to fix things when shit eventually hits the fan. Poetry just made a breaking change with 1.2 for example with the "brown outs" for get-poetry.py. Another fun problem is poetry by default having an open "upper bound" for dependencies. Also poetry can't even infer from pypy about a dependencies of a package, pypi devs have deemed that problem as "will not fix". Which is balls. So poetry has to download a package, inspect its deps, and then continue resolving the graph. It's an absolute mess. I appreciate everyone that does work on that because it is not easy.
https://pyscript.net this is pretty new. I would assume it would be pretty useful if browsers start including the interpreter
Maybe you're looking for https://github.com/beartype/beartype for runtime type enforcement; it's only at function calls, though, but probably a decent solution for codebases that are not completely typed for MyPy or pyright.
How about scalene?
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