pico-micropython-examples VS Adafruit_BME280_Library

You would have to look at the code to be sure. (I'm too lazy to look.) But if you want, you can use this code to ensure that you are using the PIO hardware (and that wouldn't have problems with interrupts): https://github.com/raspberrypi/pico-micropython-examples/blob/master/pio/pio_pwm.py

You can then look at the MicroPython pico examples and try adding the adc code to read the onboard temperature, and send it in the request. Then you can look for help on using the Adafruit_DHT code. Take small steps.

Python already exists for the pico. It is a micropython port. Once you've downloaded it, you have an interactive Python prompt and a filesystem you can place a main.py file in to run at reboot. MicroPython is a fantastic way to start with microprocessors.

Thank you so much for your help. is resp=b"" equal to resp=bytes() ? and why the author did not use decode or encode? see this please-> https://github.com/raspberrypi/pico-micropython-examples/blob/master/uart/loopback/uart.py

When working with the Pico and MicroPython, I've found an endless amount of use from the Pico MicroPython Examples repository on GitHub.

Line 7 - 9: Pio assembler commands as documented in the official documentation. In MicroPython, there are subtle differences to the naming conventions, so be sure to read the community documentation and also browse the examples

Examples: https://github.com/raspberrypi/pico-micropython-examples

To begin reading sensor data, you will need to install the Adafruit_BME280 library (code on Adafruit github repository). Available from the Arduino library manager.

Here's the initialization section of the Adafruit BME280 library

It's C-with-classes C++ at least: Adafruit_BME280_Library/Adafruit_BME280.h at master · adafruit/Adafruit_BME280_Library (github.com)