make-booster VS tes-azure-legacy

For a very different approach, check out make-booster:

https://github.com/david-a-wheeler/make-booster

Make-booster provides utility routines intended to greatly simplify data processing (particularly a data pipeline) using GNU make. It includes some mechanisms specifically to help Python, as well as general-purpose mechanisms that can be useful in any system. In particular, it helps reliably reproduce results, and it automatically determines what needs to run and runs only that (producing a significant speedup in most cases). Released as open source software.

https://github.com/david-a-wheeler/make-booster

I think a lot of hate on make is due to poor use. If your makefile is complex, refactor it. Auto-generate dependencies (it only takes a few lines in GNU make). And don't use recursive make, that way lies madness. I also think GNU make is the wiser tool; POSIX make lacks too much in many cases.

https://github.com/david-a-wheeler/make-booster

From its readme:

"This project (contained in this directory and below) provides utility routines intended to greatly simplify data processing (particularly a data pipeline) using GNU make. It includes some mechanisms specifically to help Python, as well as general-purpose mechanisms that can be useful in any system. In particular, it helps reliably reproduce results, and it automatically determines what needs to run and runs only that (producing a significant speedup in most cases)."

"For example, imagine that Python file BBB.py says include CC, and file CC.py reads from file F.txt (and CC.py declares its INPUTS= as described below). Now if you modify file F.txt or CC.py, any rule that runs BBB.py will automatically be re-run in the correct order when you use make, even if you didn't directly edit BBB.py."

This is NOT functionality directly provided by Python, and the overhead with >1000 files was 0.07seconds which we could live with :-).

Snakemake is a beautiful project and evolves and improves so fast. Years ago I realized I needed to up my game from the usual bash based NGS data processing pipelines I was writing. Based on several recommendation I choose Snakemake. I have never regretted it, It worked perfectly on our PBS cluster then on our Slurm cluster. I made some steps to make it run on K8s, which is supports, and most recently, I'm still/again happy with my choice for Snakemake because it (together with Nextflow) seems to be the chosen framework for GA4GH's cloud work stream's "products" like WES and TES [0]. This seems to be the tech stack where Amazon Omics and Microsoft Genomics focus on [1].

I owe a lot to Snakemake and Johannes Köster, I hope some day I can repay him and his project.

[0] https://www.ga4gh.org/work_stream/cloud/

[1] https://github.com/Microsoft/tes-azure