gnomad-browser VS Gravitational Teleport

try one of these: GnomAD (https://gnomad.broadinstitute.org/) 1000 Genomes (http://browser.1000genomes.org) dbSNP (http://www.ncbi.nlm.nih.gov/snp)

Maybe you can ask the opposite question; what are the bounds of of a functional human being. https://gnomad.broadinstitute.org/ GnomAD is a aggregation of healthy human genetic sequences which was primarily built on the aggregated control groups of many genetic sequencing studies. There are studies of this data analysing the co-occurrence of variants in gnomAD which may help.

Maybe something like this? https://promethease.com/ Clinvar for variants that might be of clinical relevance. https://gnomad.broadinstitute.org/ for allele frequencies & some info about variants.

You could look at aggregation databases such as gnomad https://gnomad.broadinstitute.org/ anything with a frequency incompatible with the disease is likely non pathogenic

Broad Institute of MIT and Harvard | Cambridge, MA | Frontend Software Engineer | REMOTE or HYBRID (New England area)

We are hiring a frontend developer to help lead the next phase of the gnomAD browser, a web application for displaying the world's largest collection of human genome/exome sequences. https://gnomad.broadinstitute.org. Looking for applicants who are excited about data visualization and designing complex interfaces for scientific research.

Apply here: http://broad.io/cq7dw8

Broad Institute of MIT and Harvard | New England | Software Engineer | REMOTE/HYBRID

Our team is focused on building the tools necessary to visualize and interpret massive data sets of human genetic variation and functional genomic information. We have developed gnomAD (https://gnomad.broadinstitute.org), the world’s largest public reference dataset of human exomes and genomes. gnomAD has become one of the most widely used resources in the field, and is now the default reference database for virtually all clinical interpretation pipelines, as well as a standard analysis resource for a wide variety of genetic and biological studies. We estimate gnomAD has contributed to the clinical diagnosis of over 2 million patients with genetic disorders.

Your role will be to maintain the gnomAD browser, our open source web application for exploring gnomAD and related datasets, and develop new scientific functionality as we continue to grow to over 1 million human samples. You will work with a team of software engineers, computational biologists and clinical and research users to develop new features and visualizations that incorporate user feedback. Software engineering skills and an interest in user interface design and data visualization are key. Basic familiarity with genomics and DNA sequencing data is preferred, but not required. Most importantly, the ideal candidate will have enthusiasm for playing a critical role in a team-oriented project and learning new domains.

Minimum Requirements

If you're talking about humans, start with gnomAD: https://gnomad.broadinstitute.org/

https://github.com/gravitational/teleport/blob/master/rfd/00...

I ordinarily would have said you reinvented Teleport <https://github.com/gravitational/teleport/tree/v14.3.7#readm...> but now that they've gone AGPL with v15 I'm guessing there's a market for MIT licensed stuff, although for sure since Teleport has been around for so long it has encountered more edge cases and undergone more security reviews. I was surprised while digging up the link that Gravatational is still releasing v13 and v14 updates under Apache 2, so maybe even Teleport will continue to have legs for those who cannot deploy AGPL stuff

Teleport is an SSH for Clusters and Teams and aims to be the drop-in replacement for OpenSSH.

Are you looking to set up SSO for your cloud infrastructure? Or maybe establish tunnels to access services behind NATs and firewalls. Then Teleport is for you. It provides connectivity, authentication, access controls and audit for infrastructure. The newest update has a tonne of new features and improvements including enhanced device trust support, SSH connection resumption, MFA for admin actions, improved provisioning for Okta, and heaps. more. Check out all the changes in the Teleport release notes.

In case you didn't see it: https://goteleport.com/blog/teleport-oss-switches-to-agpl-v3... and https://github.com/gravitational/teleport/pull/35259

I readily admit it's not the same amount of :fu: as BuSL or whatever the fuck is going on over at Sentry but still :-( as compared to their much friendlier Apache 2

Link to GitHub -->

OP here, thanks for posting! Happy to Answer any questions. I have to give our a shoutout to Alan at Teleport for all his work on Passwordless and his work to make Passwordless / TouchID work with MacOS CLI https://github.com/gravitational/teleport/blob/master/rfd/00...

I work on the Desktop Access feature for Teleport: https://goteleport.com/docs/desktop-access/getting-started/

The tool itself is open core: https://github.com/gravitational/teleport

Most of the desktop access stuff is open source. The only desktop related thing that's proprietary is our tool that allows for access to machines not connected to Active Directory. A sizeable chunk of the desktop access code is even Written In Rust™: https://github.com/gravitational/teleport/tree/master/lib/sr...!