gnomad-browser
Sentry
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gnomad-browser | Sentry | |
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15 | 266 | |
78 | 36,886 | |
- | 1.3% | |
9.7 | 10.0 | |
3 days ago | 4 days ago | |
TypeScript | Python | |
MIT License | GNU General Public License v3.0 or later |
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Activity is a relative number indicating how actively a project is being developed. Recent commits have higher weight than older ones.
For example, an activity of 9.0 indicates that a project is amongst the top 10% of the most actively developed projects that we are tracking.
gnomad-browser
- All identified polymorphisms in a given gene, how to find?
- AskScience AMA Series: We're human genetics researchers here to discuss connections between people in different geographical regions. Ask us anything!
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Converting 23&Me raw data into a format usable by Admixtools 2
try one of these: GnomAD (https://gnomad.broadinstitute.org/) 1000 Genomes (http://browser.1000genomes.org) dbSNP (http://www.ncbi.nlm.nih.gov/snp)
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What is the maximum number of human?
Maybe you can ask the opposite question; what are the bounds of of a functional human being. https://gnomad.broadinstitute.org/ GnomAD is a aggregation of healthy human genetic sequences which was primarily built on the aggregated control groups of many genetic sequencing studies. There are studies of this data analysing the co-occurrence of variants in gnomAD which may help.
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Insights from personal sequencing data I can explore.
Maybe something like this? https://promethease.com/ Clinvar for variants that might be of clinical relevance. https://gnomad.broadinstitute.org/ for allele frequencies & some info about variants.
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What are some non-pathogenic alleles of the SNCA gene, or how do I find them?
You could look at aggregation databases such as gnomad https://gnomad.broadinstitute.org/ anything with a frequency incompatible with the disease is likely non pathogenic
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Ask HN: Who is hiring? (March 2022)
Broad Institute of MIT and Harvard | Cambridge, MA | Frontend Software Engineer | REMOTE or HYBRID (New England area)
We are hiring a frontend developer to help lead the next phase of the gnomAD browser, a web application for displaying the world's largest collection of human genome/exome sequences. https://gnomad.broadinstitute.org. Looking for applicants who are excited about data visualization and designing complex interfaces for scientific research.
Apply here: http://broad.io/cq7dw8
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Ask HN: Who is hiring? (February 2022)
Broad Institute of MIT and Harvard | New England | Software Engineer | REMOTE/HYBRID
Our team is focused on building the tools necessary to visualize and interpret massive data sets of human genetic variation and functional genomic information. We have developed gnomAD (https://gnomad.broadinstitute.org), the world’s largest public reference dataset of human exomes and genomes. gnomAD has become one of the most widely used resources in the field, and is now the default reference database for virtually all clinical interpretation pipelines, as well as a standard analysis resource for a wide variety of genetic and biological studies. We estimate gnomAD has contributed to the clinical diagnosis of over 2 million patients with genetic disorders.
Your role will be to maintain the gnomAD browser, our open source web application for exploring gnomAD and related datasets, and develop new scientific functionality as we continue to grow to over 1 million human samples. You will work with a team of software engineers, computational biologists and clinical and research users to develop new features and visualizations that incorporate user feedback. Software engineering skills and an interest in user interface design and data visualization are key. Basic familiarity with genomics and DNA sequencing data is preferred, but not required. Most importantly, the ideal candidate will have enthusiasm for playing a critical role in a team-oriented project and learning new domains.
Minimum Requirements
- Ask HN: How to be my own genetic disease researcher for my partner?
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How to check if a discovered mutation is novel or was discovered before ?
If you're talking about humans, start with gnomAD: https://gnomad.broadinstitute.org/
Sentry
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Building a Production-Ready Web App with T3 Stack
First, sign up for a free account at https://sentry.io. Create a new project and make note of your DSN (Data Source Name).
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How to Handle N+1 Queries for Optimal Database Performance in Django?
Using APM tools like NewRelic, Sentry, Datadog, etc to monitor the performance of your application and while you're on it, they can help you identify N+1 queries.
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Next.js Error Monitoring with Sentry: Enhancing Your Application’s Reliability
However, ensuring the reliability and performance of your Next.js app is equally crucial. That’s where Sentry comes into play. Combined with Sentry, an industry-leading error monitoring platform, Next.js empowers developers to proactively identify and resolve issues that may arise in their applications. In this article, we’ll explore how to integrate Sentry into your Next.js project for effective error monitoring and performance optimization.
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4 facets of API monitoring you should implement
Sentry: Error monitoring for applications, including APIs. Also offers application performance monitoring (APM).
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It's 29 Delphi, I mean
Indeed, webapps are not immune to distribution problems. Wayward and invasive browser extensions are a clear threat, as are 3rd-party dependencies (and their dependencies) loaded at runtime. Which is why companies like https://sentry.io exist. I think the difference is that webapps are "distributable by default" and it takes real work to break this. Versus having local desktop apps which require work to distribute. A potent example of the power of defaults.
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We removed advertising cookies, here's what happened
Sentry produces nothing of value? You don't value an open source error tracking and performance monitoring platform? https://github.com/getsentry/sentry
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The Life and Death of Open Source Companies
> You invent something, and then immediately turn it into a cheap commodity by releasing it for free.
Exactly. A 71-line python script https://github.com/getsentry/sentry/commit/3c2e87573d3bd16f6... was groundbreaking when it came out and the fact that it springboarded into a startup is commendable.
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banner ads in spotify
sentry.io: 5
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Open Source alternatives to tools you Pay for
Sentry - Open Source Alternative For Error Tracking
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🤩 20 Awesome Tools For Your Web Dev Toolkit 🛠️
11. Sentry
What are some alternatives?
webviz - web-based visualization libraries
jaeger - CNCF Jaeger, a Distributed Tracing Platform
haystack - :mag: LLM orchestration framework to build customizable, production-ready LLM applications. Connect components (models, vector DBs, file converters) to pipelines or agents that can interact with your data. With advanced retrieval methods, it's best suited for building RAG, question answering, semantic search or conversational agent chatbots.
Loguru - Python logging made (stupidly) simple
metamask-extension - :globe_with_meridians: :electric_plug: The MetaMask browser extension enables browsing Ethereum blockchain enabled websites
opentelemetry-specification - Specifications for OpenTelemetry
aioli - Framework for building fast genomics web tools with WebAssembly and WebWorkers
skywalking - APM, Application Performance Monitoring System
Baserow - Open source no-code database and Airtable alternative. Create your own online database without technical experience. Performant with high volumes of data, can be self hosted and supports plugins
PostHog - 🦔 PostHog provides open-source product analytics, session recording, feature flagging and A/B testing that you can self-host.
FrameworkBenchmarks - Source for the TechEmpower Framework Benchmarks project
Grafana - The open and composable observability and data visualization platform. Visualize metrics, logs, and traces from multiple sources like Prometheus, Loki, Elasticsearch, InfluxDB, Postgres and many more.