gnomad-browser VS Mattermost

try one of these: GnomAD (https://gnomad.broadinstitute.org/) 1000 Genomes (http://browser.1000genomes.org) dbSNP (http://www.ncbi.nlm.nih.gov/snp)

Maybe you can ask the opposite question; what are the bounds of of a functional human being. https://gnomad.broadinstitute.org/ GnomAD is a aggregation of healthy human genetic sequences which was primarily built on the aggregated control groups of many genetic sequencing studies. There are studies of this data analysing the co-occurrence of variants in gnomAD which may help.

Maybe something like this? https://promethease.com/ Clinvar for variants that might be of clinical relevance. https://gnomad.broadinstitute.org/ for allele frequencies & some info about variants.

You could look at aggregation databases such as gnomad https://gnomad.broadinstitute.org/ anything with a frequency incompatible with the disease is likely non pathogenic

Broad Institute of MIT and Harvard | Cambridge, MA | Frontend Software Engineer | REMOTE or HYBRID (New England area)

We are hiring a frontend developer to help lead the next phase of the gnomAD browser, a web application for displaying the world's largest collection of human genome/exome sequences. https://gnomad.broadinstitute.org. Looking for applicants who are excited about data visualization and designing complex interfaces for scientific research.

Apply here: http://broad.io/cq7dw8

Broad Institute of MIT and Harvard | New England | Software Engineer | REMOTE/HYBRID

Our team is focused on building the tools necessary to visualize and interpret massive data sets of human genetic variation and functional genomic information. We have developed gnomAD (https://gnomad.broadinstitute.org), the world’s largest public reference dataset of human exomes and genomes. gnomAD has become one of the most widely used resources in the field, and is now the default reference database for virtually all clinical interpretation pipelines, as well as a standard analysis resource for a wide variety of genetic and biological studies. We estimate gnomAD has contributed to the clinical diagnosis of over 2 million patients with genetic disorders.

Your role will be to maintain the gnomAD browser, our open source web application for exploring gnomAD and related datasets, and develop new scientific functionality as we continue to grow to over 1 million human samples. You will work with a team of software engineers, computational biologists and clinical and research users to develop new features and visualizations that incorporate user feedback. Software engineering skills and an interest in user interface design and data visualization are key. Basic familiarity with genomics and DNA sequencing data is preferred, but not required. Most importantly, the ideal candidate will have enthusiasm for playing a critical role in a team-oriented project and learning new domains.

Minimum Requirements

If you're talking about humans, start with gnomAD: https://gnomad.broadinstitute.org/

> Tell me another platform that is free, has realtime chat, voice and video, has stable service, allows sharing images and other media, with good ownership management... and is open source.

Mattermost: https://mattermost.com/

Rocket.Chat: https://www.rocket.chat/

Nextcloud Talk: https://nextcloud.com/talk/

Self hosting and some assembly required. I've run all of them on cheap VPSes to explore a Slack/Discord replacement, neither was mindblowing but all of them seemed okay (Nextcloud's offering was rather barebones, though).

Audio and video support varies because getting those right is challenging, at best you'd just integrate with something like Jitsi, that one's actually pretty good for meetings and such: https://jitsi.org/ and has a cloud version too: https://meet.jit.si/ (yet people still go for Zoom and it's odd UI/UX choices)

I actually rather liked forums back in the day, but I guess nobody will be setting up that many phpBB instances in the current year, though projects like Discourse also seem promising: https://www.discourse.org/

I don't think many people at all will be leaving Discord, due to how entrenched the platform is (network effect): if you want people to help you with what you're working on, you go where they are, not vice versa.

Mattermost, Inc. | Senior React Native Engineer | REMOTE (US Only) | Full-Time

At Mattermost we build an open core, chat and collaboration platform focused on making users with mission critical work more productive while also allowing our customers to self-deploy and have full control over their own data.

We’re looking for a Senior React Native Engineer who has the depth to significantly move the performance needle of our app while also having the breadth to contribute across our stack.

Check out our open source mobile codebase: https://github.com/mattermost/mattermost-mobile. Meta uses the Mattermost RN app as the benchmark for performance testing of their Hermes JS engine: https://mattermost.com/blog/hermes-mattermost/. Want to set the bar for what a complex, high performing React Native app can do? Want to do it open source? Join our team!

Apply here: https://jobs.lever.co/mattermost/a38ea8f0-6c27-4178-a988-801...

Mattermost for Chat, and also for Notifications sent by Uptime-Kuma

Mattermost offers a secure, open-source solution for seamless collaboration throughout the software development lifecycle. Tailored to cater to technical and operational needs, it easily integrates with a wide range of third-party developer tools—to streamline development and engineering workflows. With self-hosted and private cloud deployment options, coupled with access to the source code, you have complete control over the data via a shared, adaptable, and extensible platform designed specifically for your team. Kindly suggested by Molasses_Major.

FWIW, most of the TypeScript lines of code are in the E2E tests[0] and the webapp dir [1], which, as the name suggests, contains "the client code for the Mattermost web app". So we should really only be counting lines of Go code.

[0] https://github.com/mattermost/mattermost/tree/master/e2e-tes...

[1] https://github.com/mattermost/mattermost/tree/master/webapp

Mattermost is an good alternative to companies, workers and teams.

oder auch Mattermost

Revolt, Guilded, Element (Matrix Client), Matrix, Cinny (Matrix Client), Spacebar, Rocket Chat, Mikoto, Mattermost, Teamspeak and Nertivia

might be overkill but https://mattermost.com/

But it seems that you're right for Mattermost.