gnomad-browser VS hackclub

try one of these: GnomAD (https://gnomad.broadinstitute.org/) 1000 Genomes (http://browser.1000genomes.org) dbSNP (http://www.ncbi.nlm.nih.gov/snp)

Maybe you can ask the opposite question; what are the bounds of of a functional human being. https://gnomad.broadinstitute.org/ GnomAD is a aggregation of healthy human genetic sequences which was primarily built on the aggregated control groups of many genetic sequencing studies. There are studies of this data analysing the co-occurrence of variants in gnomAD which may help.

Maybe something like this? https://promethease.com/ Clinvar for variants that might be of clinical relevance. https://gnomad.broadinstitute.org/ for allele frequencies & some info about variants.

You could look at aggregation databases such as gnomad https://gnomad.broadinstitute.org/ anything with a frequency incompatible with the disease is likely non pathogenic

Broad Institute of MIT and Harvard | Cambridge, MA | Frontend Software Engineer | REMOTE or HYBRID (New England area)

We are hiring a frontend developer to help lead the next phase of the gnomAD browser, a web application for displaying the world's largest collection of human genome/exome sequences. https://gnomad.broadinstitute.org. Looking for applicants who are excited about data visualization and designing complex interfaces for scientific research.

Apply here: http://broad.io/cq7dw8

Broad Institute of MIT and Harvard | New England | Software Engineer | REMOTE/HYBRID

Our team is focused on building the tools necessary to visualize and interpret massive data sets of human genetic variation and functional genomic information. We have developed gnomAD (https://gnomad.broadinstitute.org), the world’s largest public reference dataset of human exomes and genomes. gnomAD has become one of the most widely used resources in the field, and is now the default reference database for virtually all clinical interpretation pipelines, as well as a standard analysis resource for a wide variety of genetic and biological studies. We estimate gnomAD has contributed to the clinical diagnosis of over 2 million patients with genetic disorders.

Your role will be to maintain the gnomAD browser, our open source web application for exploring gnomAD and related datasets, and develop new scientific functionality as we continue to grow to over 1 million human samples. You will work with a team of software engineers, computational biologists and clinical and research users to develop new features and visualizations that incorporate user feedback. Software engineering skills and an interest in user interface design and data visualization are key. Basic familiarity with genomics and DNA sequencing data is preferred, but not required. Most importantly, the ideal candidate will have enthusiasm for playing a critical role in a team-oriented project and learning new domains.

Minimum Requirements

If you're talking about humans, start with gnomAD: https://gnomad.broadinstitute.org/

OMG I love this. Go get em! Also, this is perfect material for Hack Club. You should join! https://hackclub.com/

Hi! I'm Lexi, I wrote this article/mini-book. There's a classic question of "what happens when you load a website?", but I've always been more interested in "what happens when you run a program?". About 3 months ago, I was really annoyed at myself for not knowing how to answer that question so I decided to teach myself.

I taught myself everything else I know in programming, so this should be easy, right? NOPE! Apparently everything online about how operating systems and CPUs work is terrible. There are, like, no resources. Everything sucks. So while I was teaching myself I realized, hey, I should make a really good resource myself. So I started taking notes on what I was learning, and ended up with a 60-page Google Doc. And then I started writing.

And while I was writing, it turned out that most of the stuff in that giant doc was wrong. And I had to do more research. And I iterated and iterated and iterated and the internet resources continued to be terrible so I needed to make the article better. Then I realized it needed diagrams and drawings, but I didn't know how to do art, so I just pulled out Figma and started experimenting. I had a Wacom tablet lying around that I won at some hackathon, so I used that to draw some things.

Now, about 3 months later, I have something I'm really proud of! I'm happy to finally share the final version of Putting the "You" in CPU. I built this as part of Hack Club (https://hackclub.com), which is a community of other high schoolers who love computers.

It was cool seeing some (accidental) reception on HN a couple weeks ago while this was still a WIP, I really appreciated the feedback I got. I took some time to substantially clean it up and I'm finally happy to share with the world myself.

The website is a static HTML/CSS project, I wrote everything from scratch (I'm especially proud of the navigation components).

I hope you enjoy and learn something!

Hi! I'm the person who made this thing!

Some backstory on me: I'm 17 and left high school a year ago to work full-time at Hack Club (https://hackclub.com/). I've been programming for as long as I can remember, and started homeschooling about 6 years ago to focus more on that (and my other interests).

Since I'm entirely self-taught, I haven't taken any college systems classes — and while I had picked up a lot, I wasn't happy with my answer to "what happens when you run a thing." So I let myself spend a shit ton of time actually learning as much as possible. What I found was that:

1. Operating systems and hardware are really fun to learn about!

In the face of the recent devastating floods in Vermont, Hack Club, a Vermont-based nonprofit, is offering free use of Hack Club Bank for any flood relief efforts in Vermont, New York State, and New Hampshire.

Facing recent floods, Hack Club is offering free use of Hack Club Bank for relief efforts in VT, NY, and NH. Collect tax-deductible donations easily through various platforms, including GoFundMe. Manage funds collaboratively on our easy-to-use online platform, and issue physical or virtual cards for your charitable expenses. As Vermonters, we’re eager to assist fellow Vermonters. Start within 24 hours by emailing [[email protected]](mailto:[email protected]) or filling out the form on https://hackclub.com/bank.

Something like https://hackclub.com/

FIRST alumni and founder of Hack Club here.

Hack Club is a nonprofit network of hackathons, student-led coding clubs, and open source projects. Our website is https://hackclub.com and our GitHub is https://github.com/hackclub.

We have been receiving free email hosting from Google Workspace and providing it to the Hack Club network, but we recently hit the domain limit (600 domains) on Google Workspace for Nonprofits. Each domain is typically a hackathon or a chapter at a high school.

Does anyone have any recommendations for email hosts that we could look into? As a mostly volunteer-driven nonprofit, we can't afford pay per-user pricing as there are thousands and thousands of accounts.