gnomad-browser
web
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gnomad-browser | web | |
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15 | 157 | |
78 | 1,767 | |
- | 0.9% | |
9.7 | 6.4 | |
3 days ago | 9 months ago | |
TypeScript | JavaScript | |
MIT License | GNU General Public License v3.0 or later |
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gnomad-browser
- All identified polymorphisms in a given gene, how to find?
- AskScience AMA Series: We're human genetics researchers here to discuss connections between people in different geographical regions. Ask us anything!
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Converting 23&Me raw data into a format usable by Admixtools 2
try one of these: GnomAD (https://gnomad.broadinstitute.org/) 1000 Genomes (http://browser.1000genomes.org) dbSNP (http://www.ncbi.nlm.nih.gov/snp)
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What is the maximum number of human?
Maybe you can ask the opposite question; what are the bounds of of a functional human being. https://gnomad.broadinstitute.org/ GnomAD is a aggregation of healthy human genetic sequences which was primarily built on the aggregated control groups of many genetic sequencing studies. There are studies of this data analysing the co-occurrence of variants in gnomAD which may help.
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Insights from personal sequencing data I can explore.
Maybe something like this? https://promethease.com/ Clinvar for variants that might be of clinical relevance. https://gnomad.broadinstitute.org/ for allele frequencies & some info about variants.
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What are some non-pathogenic alleles of the SNCA gene, or how do I find them?
You could look at aggregation databases such as gnomad https://gnomad.broadinstitute.org/ anything with a frequency incompatible with the disease is likely non pathogenic
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Ask HN: Who is hiring? (March 2022)
Broad Institute of MIT and Harvard | Cambridge, MA | Frontend Software Engineer | REMOTE or HYBRID (New England area)
We are hiring a frontend developer to help lead the next phase of the gnomAD browser, a web application for displaying the world's largest collection of human genome/exome sequences. https://gnomad.broadinstitute.org. Looking for applicants who are excited about data visualization and designing complex interfaces for scientific research.
Apply here: http://broad.io/cq7dw8
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Ask HN: Who is hiring? (February 2022)
Broad Institute of MIT and Harvard | New England | Software Engineer | REMOTE/HYBRID
Our team is focused on building the tools necessary to visualize and interpret massive data sets of human genetic variation and functional genomic information. We have developed gnomAD (https://gnomad.broadinstitute.org), the world’s largest public reference dataset of human exomes and genomes. gnomAD has become one of the most widely used resources in the field, and is now the default reference database for virtually all clinical interpretation pipelines, as well as a standard analysis resource for a wide variety of genetic and biological studies. We estimate gnomAD has contributed to the clinical diagnosis of over 2 million patients with genetic disorders.
Your role will be to maintain the gnomAD browser, our open source web application for exploring gnomAD and related datasets, and develop new scientific functionality as we continue to grow to over 1 million human samples. You will work with a team of software engineers, computational biologists and clinical and research users to develop new features and visualizations that incorporate user feedback. Software engineering skills and an interest in user interface design and data visualization are key. Basic familiarity with genomics and DNA sequencing data is preferred, but not required. Most importantly, the ideal candidate will have enthusiasm for playing a critical role in a team-oriented project and learning new domains.
Minimum Requirements
- Ask HN: How to be my own genetic disease researcher for my partner?
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How to check if a discovered mutation is novel or was discovered before ?
If you're talking about humans, start with gnomAD: https://gnomad.broadinstitute.org/
web
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Octant is donating 1M in ETH to 10 public goods projects, and you can help decide how to allocate.
Here's the list of projects you can support: Clr.fund - https://clr.fund/ DAO Drops - https://daodrops.io/ Drips - https://www.drips.network/ Ethereum Cat Herders - https://www.ethereumcatherders.com ETHStaker - https://ethstaker.cc Giveth - https://giveth.io/ Gitcoin - https://gitcoin.co Kernel - https://www.kernel.community/en/ Protocol Guild - https://protocol-guild.readthedocs.io Supermodular - https://supermodular.xyz/
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Daily General Discussion - April 12, 2023
The Gitcoin website has some of the worst information architecture, I have no idea what their team is doing. I can't imagine how many people visited gitcoin.co to donate and couldn't figure out how.
- Thoughts on building an ETH dominated portolio?
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Best Websites For Coders
GitCoin : Gitcoin is the easiest way to monetize or incentivize work in Open Source Software.
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Do you as a socialist consider blockchain tech as a path towards a worker-owned means of production? It’s the primary goal of many crypto projects.
Also, check out Gitcoin: https://gitcoin.co/ (which coincidentally does have a token) but has funneled over $65m directly to open source software developers. They’ve also recently formed a foundation that is governed by the token holders.
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How can i work online for crypto?
Check out https://gitcoin.co/!
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The Importance of Cryptocurrency to Web 3 and the Future of Decentralization
If you want to get involved then I suggest going to https://gitcoin.co/
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Reminder for people interested in Bisq to get involved in discussing proposals on GitHub
There's other projects that have tried implementing something similar though.
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Nano bounty program
Check out https://gitcoin.co. They provide a platform for web3 projects to provide bounties to people creating for projects.
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Making money with ethdev projects?
gitcoin.co has bounties and hackathons with prizes.
What are some alternatives?
webviz - web-based visualization libraries
opensea-js - TypeScript SDK for the OpenSea marketplace
haystack - :mag: LLM orchestration framework to build customizable, production-ready LLM applications. Connect components (models, vector DBs, file converters) to pipelines or agents that can interact with your data. With advanced retrieval methods, it's best suited for building RAG, question answering, semantic search or conversational agent chatbots.
rotki - A portfolio tracking, analytics, accounting and management application that protects your privacy
metamask-extension - :globe_with_meridians: :electric_plug: The MetaMask browser extension enables browsing Ethereum blockchain enabled websites
openzeppelin-contracts - OpenZeppelin Contracts is a library for secure smart contract development.
aioli - Framework for building fast genomics web tools with WebAssembly and WebWorkers
hevm - Dapp, Seth, Hevm, and more
Baserow - Open source no-code database and Airtable alternative. Create your own online database without technical experience. Performant with high volumes of data, can be self hosted and supports plugins
Gravitational Teleport - The easiest, and most secure way to access and protect all of your infrastructure.
FrameworkBenchmarks - Source for the TechEmpower Framework Benchmarks project
quadratic-funding - This is an open source implementation of quadratic funding, a design for philanthropic and publicly-funded seeding, which allows for optimal provisioning of funds to an ecosystem of public goods.