fossa-cli VS bonito

> where we provide lockfiles that are individually valid

Providing lockfiles is a really interesting idea! That certainly solves the "we need your non-deterministic build tool to reproduce an exact build that we found" problem.

We haven't explored this route yet because a lot of our customers use tools that don't support lockfiles (e.g. Maven - Java in general has a lot of legacy stuff).

If you want to build off of our work, our dependency analysis bit is open source: https://github.com/fossas/fossa-cli

FOSSA | Software Engineers (Mid, Sr., Staff), PMs (Mid, Sr.) | USA, Canada, Remote (able to work ~US time zone hours)| Full-Time

FOSSA builds developer tools to help engineering teams manage their open source. We help enterprise customers discover legal (licensing and copyright) and security (vulnerabilities) risks in their dependencies, provide tooling for them to catch these issues in CI, and automate the tedium around policy enforcement and report generation. As companies adopt more open source, their engineering teams get bogged down by more distractions around compliance and security. We help automate away those distractions.

We build an open-source CLI tool (https://github.com/fossas/fossa-cli) that integrates with compilers and build systems to extract dependency and build information; a backend distributed system for analyzing dependency metadata; and a web application with a policy, reporting, and enforcement engine.

Tech we use includes:

The project I'm trying to build is open source (https://github.com/fossas/fossa-cli). When I got this new system set up, I ran the instructions on our HACKING.md page and immediately tried to build. This failed because I didn't have `llvm` installed, so I `brew install llvm`'d, symlinked into `$PATH`, and tried again. This failed due to: ``` install_name_tool: error: unsupported load command (cmd=0x80000034) `install_name_tool' failed in phase `Install Name Tool'. (Exit code: 1)

There is a technology called Nanopore. I’ve never used it myself but the concept was to be able to sequence samples of nucleic acid out in the field. A quick pubmed search indicated that it can detect miRNA, but maybe with some modifications. https://nanoporetech.com Best of luck with it!

> An unpopular opinion: there are too many other logos that look like the original logo

There are also too many logos that look like the new logo. The first blue circle logos that spring to mind are Blue Circle Cement/Tarmac/Lafarge [1] and Oxford Nanopore [2].

[1]: https://en.wikipedia.org/wiki/Tarmac_(company)

[2]: https://nanoporetech.com/

Oxford Nanopore Technologies (https://nanoporetech.com/) | Front end developer | Full-time | Oxford | Remote (UK)

Oxford Nanopore Technologies is headquartered at the Oxford Science Park outside Oxford, UK, with satellite offices and commercial presence in many global locations across the US, APAC and Europe. Our DNA/RNA sequencing platform is the only technology that offers real-time analysis (for rapid insights), in fully scalable formats from pocket to population scale. Our goal is to enable the analysis of any living thing, by anyone, anywhere.

Tech stack: Electron, Stencil, React, Typescript, RxJS, GRPC

For more details, please email: [email protected]

Ok this isn't really my area but I know that there are labs/companies performing these types of electrical current disturbance measurements of membrane-type proteins for both DNA sequencing (https://nanoporetech.com/) and protein sequencing (https://www.nature.com/articles/s41587-019-0401-y).

Now nanopore sequencing is solid state and gets much longer reads. https://nanoporetech.com/ and https://en.wikipedia.org/wiki/Nanopore_sequencing

Also best of luck with the basecaller, I will say that the latest guppy versions are very good, both in terms of accuracy and speed, as they are GPU accelerated and the best I've seen in accuracy. You may also be interested in Bonito, a tool to generate your own GPU basecalling model or tweak existing models to your data. https://github.com/nanoporetech/bonito.