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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
My all time favorite is Kerbalism. It doesn't make it easier, but I think it makes it more interesting/fun, especially for manned missions. It reworks the science system, and has good life support and ISRU options.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.