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Been building in this space for a while - built this with a friend of mine - https://github.com/timothystiles/poly
Most of the python packages are honestly... kind of terrible to maintain. Sure, it is easy to whip up a python script to answer your computational question, but maintaining that is extremely hard - as evidenced by the shear number of abandoned python programs written by graduate students that can no longer be run. I used to care about building things quickly, but now I just care about maintenance of things. Maintenance in computational biology is awful right now.