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There is a standard being developed named WASI (WebAssembly System Interface) which provides a sandboxed way to write local applications using WebAssembly and implementations like Wasmer.
That said support is most likely somewhere on the map and there is even an ongoing proposal to add WASM threads (https://github.com/WebAssembly/threads/blob/master/proposals/threads/Overview.md) so it is more a matter of when we will be able to create a server from a WASM module not if.
That's the old .NET ways. Most new projects using dotnet core will ship the framework independent and you can AOT lots of pieces. There is a current huge push on the dotnet ecosystem to have full AOT Here is the github issue. If you check the survey there, they even talk about the scenarios where people would pick languages such as rust or go because the AOT story for .NET is not fully there yet.