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sqlightning
SQLite3 ported to use LMDB instead of its original Btree code. See https://github.com/LumoSQL/LumoSQL for maintained fork.
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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
This has been shared without context but I guess the SQLite team is starting to modularize the btree code in order to facilitate work like SQLightning: https://github.com/LMDB/sqlightning
At the time SQLightning greatly improved SQLite performance but due to LMDB's requirement to have keys fit in 2/3 of a page it wasn't really useful as a general purpose replacement of SQLite's internal b-tree implementation.
NOTE:
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Hence, a higher number means a more popular project.