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Honestly, even that seems trivial? By my reading of https://github.com/pyston/pyston#installing-packages , the only impact is that when you install (compiled) libraries they need to be recompiled, just like if you use Alpine (which is also ABI-incompatible because it uses musl libc), which is a little bit of pain at build/packaging time but doesn't actually break anything (i.e. there are no libraries that you can't use, just libraries with an extra compile step) and doesn't affect runtime behavior at all.
Every month or so I look around to see if there's a monolithic web framework in languages I'm interested that are effectively equivalents of Django, Rails, Laravel, etc. I've done a lot of non-webapp stuff with Go, for example, and would like to build full fledged webapps with a Django-like framework in Go. But nothing like that truly exists. I've found projects like Buffalo [0] that promise this monolithic experience, but they're still very much works in progress. Even Node lacks such a true monolithic web framework from what I can tell.
[0]: https://github.com/gobuffalo/buffalo
But a JIT is already planned for a future release it’s just there’s a ton of other improvements they can do to speed it up first. See: https://github.com/markshannon/faster-cpython/blob/master/pl... where the plan is detailed.
Choosing a language is a significant factor towards the performance of your services.
A service built in go can req/resp up to 30x faster than one built in python.
https://www.techempower.com/benchmarks/#section=data-r20&hw=...
I know benchmarking isn't always the greatest, especially when the previous maintainer of Actix-Web (Rust) kind of cheated to get to the top of the leaderboard, but it still provides a decent general overview of how many responses/s a service can handle when using the same box.