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additional tools to improve python performance are also e.g. microsofts Pyjion, which enables python jit using their .net platform (apparently super easy to use, makes code twice as fast), and there is a proposal to remove the GIL (which makes parallel code a lot faster, but has some big downsides)
See e.g. CMUCL and its latter day fork SBCL, type inferencing native lisp compilers (which also had a lot of influence on the direction of various other Lisp and other language compilers).
mypyc does compile python whilst leveraging the type hints: https://github.com/mypyc/mypyc