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z88dk
The development kit for over a hundred z80 family machines - c compiler, assembler, linker, libraries.
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z88dk or sdcc come to mind. I've only done things with z88dk though because it was easier to setup for the msx platform. sdcc has more optimization but i think these days you can use it under z88dk also. Good luck, this is fun! :)
Google pointed me at https://github.com/gt-retro-computing/llvm-I8080 as an 8080 backend but I have no idea what state that is in.
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Hence, a higher number means a more popular project.