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flatpak-wine
wine using flatpak (build with runtime freedesktop sdk 22.08), provides wine to Centos like distros (https://flatpak.org/setup/)
I think Lutris doesn't recommend the use of any Proton's outside build( just the lutris builds), but you can try this, download ProtonGE https://github.com/GloriousEggroll/proton-ge-custom/releases/download/6.8-GE-1/Proton-6.8-GE-1.tar.gz, extract it on home/USER/.steam/debian-installation/compatibilitytools.d(create the folder)/, then in Lutris right click on the game or store, configure-runner options-wine version, Custom, then select below the path to ProtonGe in /home/USER/.steam/debian-installation/compatibilitytools.d/Proton-version/dist/bin/wine64, I hope it works.
try this: https://github.com/fastrizwaan/flatpak-wine-releases/releases/tag/6.4-20210510
Install dependencies https://github.com/fastrizwaan/flatpak-wine#for-the-impatient