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bread-cms
A powerful, opinionated Clojure/Script library for building custom Content Management Systems
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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
Datahike is awesome! I'll be starting a batch at the Recurse Center in a few weeks working on a CMS/library called Bread built on top of Datahike. I'm interested in a lot of these same problems and in my wanderings have come across quite a few of the tools you mention in your notes. The emphasis is more on content management and (for now) server-side rendering, but there's still quite an overlap.
I suspect it'd be too much of a mismatch to be useful, but i haven't thought about it enough. I think a more promising idea is to try implementing a database with o'doyle. I wrote about my first attempt here: Using O'Doyle Rules as a poor man's DataScript Right now it would be too inefficient for large data sets because it has to constantly rebuild its index but i think with some small changes i could improve that and basically turn o'doyle into a tool for creating databases that come with reactivity for free.