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TinyGo
Go compiler for small places. Microcontrollers, WebAssembly (WASM/WASI), and command-line tools. Based on LLVM.
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micropython-ulab
a numpy-like fast vector module for micropython, circuitpython, and their derivatives
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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
Take a look at https://tinygo.org/. It may not have less overhead than MP but it is a valid alternative.
Or maybe youre doing data science?
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.