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Real-ESRGAN
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It's not exactly what you're after, as it's anime specific and you need to process the video yourself (eg disassemble to frames, run the upscaler, then assemble back to a movie file), but Real-ESRGAN is really good:
https://github.com/xinntao/Real-ESRGAN/
It's pretty brilliant for cleaning up very old, low resolution anime.
If you want to avoid manual processing, Anime4K runs in real time as a GLSL shader you can load into MPV (or Plex or something called IINA according to the readme) and still gives great results.
https://github.com/bloc97/Anime4K
I can help:
https://hn.algolia.com/?dateRange=all&page=0&prefix=true&que...
Links found in those discussions are to some very enlightening efforts by Joel Hruska to find an upscaling solution related to what the person asked about. As somebody else mentioned, Topaz is out there and Hruska gave it a good shot, but it is not open source.