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I believe React Native can definitely handle those requirements, but it would depend on the complexity... What kind of BLE devices? I've used this react-native-ble-manager library and it was pretty straightforward to scan and connect. For notifications, I definitely recommend Notifee or maybe you can leverage Firebase for database, sync, and push notifications.
I've done a decent amount of work with bluetooth and react native. It's not particularly hard, especially the scanning and connecting. react-native-ble-plx: https://github.com/dotintent/react-native-ble-plx works great and can scan, connect, setup monitoring of ble data, or just read when needed. I can probably help you a little if you need.