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InfluxDB
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The following is a summary of the Vitest GitHub issue "Vitest runs tests 3x slower than Jest", which if printed would require about 24 pages. So I've summed up all the ideas and advice I found there into a more concise list of things you can try if you notice Vitest being slow. Please note, many performance improvements were merged into Vitest since that issue was created so not all recommendations on this page are still relevant, the goal is just to put them in one spot in an quick, concise, easy to try list.
If ShadowRealms are ever added to EcmaScript (and implemented into V8/Node) they'll allow for a different approach to isolating code that would be faster without the downsides of sharing global.