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doom-emacs
Discontinued An Emacs framework for the stubborn martian hacker [Moved to: https://github.com/doomemacs/doomemacs]
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InfluxDB
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The order in which Emacs looks at different locations for the init file is documented at How Emacs finds your Init file. You can just choose one. Most people I know use ~/.emacs.d/init.el, which has the advantages of allowing you to store other things under ~/.emacs.d/ as needed. If you use a specific configuration framework like Doom Emacs, it may ask you to store your files in specific places (e.g. ~/.doom.d/ for Doom).
I personally prefer to always specify the tangle destination specifically. Normally I set a global tangle destination for the whole file, where the majority (or all) of the blocks should be written, by having something like this at the top of the Org file (this is from my old Emacs init.org file):
This sets the default for all the emacs-lisp blocks in the file, but you can still selectively write other blocks to different files, or not at all by specifying :tangle no. This way you can easily tangle multiple destination files from a single Org file. For an example, you can see my doom.org file, from which Doom's init.el, config.el and packages.el are all tangled.