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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
The good news is that because Mastodon is open source, and development is done in the open, anyone with the needed skills and interest could implement it right, and there is a project spearheaded by cryptography experts to do just that. https://github.com/soatok/mastodon-e2ee-specification
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.