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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
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SaaSHub
SaaSHub - Software Alternatives and Reviews. SaaSHub helps you find the best software and product alternatives
There's Mezzano in active development in 2022. It says you can run in VirtualBox - in fact that's the recommended way.
awesome-lisp-machine lists several interesting projects as well.
This describes Smalltalk pretty well. https://squeak.org/ is the most popular current Smalltalk out there.
MirageOS is a runtime for OCaml to create unikernels. They describe themselves as "library operating system". Probably not quite what you were asking for, but I think it's quite interesting for certain use cases (e.g. running services as standalone unikernels in VMs or embedded devices instead of "traditional" programs on top of a general purpose OS).
CollapseOS is something similar to what you're looking for