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InfluxDB
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Lisp, and in particular Racket, has some of the most well-developed macro functionality of any language. Lisp is architected around the idea that code is represented as lists-of-lists, and macros are just ordinary Lisp functions that take lists as inputs and return lists as outputs. The only difference is that macro functions run during a different phase of a program's runtime. Racket in particular doubled down on the idea of "language-oriented programming", where the macro system is so powerful and easy to use that you can make your own Domain-Specific Language for just a single use case and have it be interoperable with other Racket code. Racket also has a foreign function interface, so you can in theory have your macro code generate calls to highly-optimized C library code, but there will always be some overhead associated with using a garbage-collected dynamically-typed language like Racket. I definitely recommend checking it out though, if nothing else because it's a mind-expanding learning experience.
I start with a simple relational language https://tablam.org and now need to supply how to build forms and APIs and all that.
I've written a proof of concept programming language explicitly for this purpose called rumi. Take a look https://github.com/mcsh/rumi . The thing that makes this possible is a macro language that is basically the language itself, and can communicate with the compiler to define macros / query syntax / change the generated code etc. Basically you have the power to write an entirely new programming language with the macros.