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As others have said, they use Solana's JSON RPC to interact with the blockchain, in Solscan's case it's mostly fetching the data. For JavaScript we have an official SDK: @solana/web3.js
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I'm building one for Python :) Solathon
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We have one decent Python SDK: [Solana.py](https://github.com/michealhly/solana.py) However the documentation isn't that great and it's kinda confusion also not really beginner friendly. My goal is to make Solathon much easier, optimized and packed with more features such as Blockchain storage, NFTs, Web3 authorization and Solana pay in future as well! Right now I'm working alone so development is not super fast but I'm trying my best :)