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dota2ai
Ranked Matchmaking AI: An improved Dota2 AI based on Valve's default AI. Has more than 3 million subscribers on Steam.
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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
Dota 2 has a bot scripting API. A popular one is https://github.com/adamqqqplay/dota2ai, which builds on the default Valve bot logic to try and produce a relatively intelligent bot for practicing offline. You might find some good knowledge in there.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.