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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
I would use snippy for this if there references are haploid genomes https://github.com/tseemann/snippy
That's helpful to know, actually. I recommend looking through the abundant tools for analysis of CRISPR experiments. I would guess someone out there has a tool for assessing cut efficacy from NGS/amplicon reads. https://github.com/davidliwei/awesome-CRISPR is a good place to start, and if you don't find what you need, make your own and publish it. ;)
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