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I think the current state of the art in this area is GraalVM. It comes with support for many languages, including Python, Ruby, R, as well as all languages that use the JVM and LLVM with a consistent memory model. You can pass things around from language to language and it should pretty much just work.
The new Enso language targets GraalVM for the purpose of seamless cross-language interop.
Have you used GraalPython? According to its GH README and its graalvm.org FAQ:
NQP is a compiler compiler toolkit that targets multiple backends: JVM, JS, and MoarVM.
Rakudo is a Raku compiler that targets NQP.