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Short answer is no. You can seamlessly interface with anything that fulfills the callbag spec, which is a specification for functions. That said, you can easily convert callbags to observables and vice versa, so I don't think there will be much issue there.
To go even one step further: Callbag JSX is basically render JSX + callbag plugins. That is done by some simple rendering plugins, so you can easily integrate any interface, even objects not necessarily complying with the callbag protocol or Observable interface, to work, by writing similar plugins.
On typing: callbag-expr is actually fully typed, and I have not yet encountered a situation where the type inference has became awkward (or even explicit, for that matter). In case it does need assistance in type inference, $ function accepts a type argument which can be used, though I have not yet encountered a situation where that is necessary (or don't recall it at least atm).