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Perhaps search hnn for "cryptocat" which was an attempt to do e2e chat through a website a dozen years ago. It was somewhat controversial at the time.
https://hn.algolia.com/?q=cryptcat
The author gave up on it after a while and the website stopped working.
[where this model breaks down] -- Alice and Bob go to your website and have a conversation. Eve hacks into the website and modifies the E2EE code. She can switch between serving the normal webapp and the malicious non-E2EE webapp. There's no good way to detect it. There are people out there who really like end to end security, but don't like browser-based e2ee because it doesn't have end to end security.
Note: https://www.cyph.com/ is a bbE2EE chat system.