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You might like Deno's Fresh: https://fresh.deno.dev/
They have a lot of cool backend tools these days, but I'm not sure they're all what you're looking for exactly. tRPC is great for communicating with your backend, but you still need to use something like Express, or their Fetch support. Prisma is great for communicating with the database when you need simple CRUD functionality and whatnot, and if I remember correctly you can extend it if that's something you absolutely need. I just found recently in the Zod docs a generator library which takes your Prisma schema and generates Zod schemas, as well as writes your CRUD router based on your Prisma schema with tRPC. At that point, you'd just need to connect with your actual Express (or similar) server, and you're set. But all that said, tRPC has integrations with Nest, Express, even options for SSR, so if you want type-safe calls to the backend, it's a solid option. I also hear good things about Nest, if you're into the Angular-like experience. It really is up to you, there's a lot of options.
