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spamassassin or rspamd or ASSP. All very good. Spamassassin just works, but you need to feed it a good cohort of spam and ham (about 1000 messages each). Most people only send it the spam which will then bias it quite a bit and not have it classify spam as spam unless it's the worst of the bunch. Spamassassin is a filter for your mail server. rspamd is the same idea. ASSP is highly configurable and a proxy.
However, https://mailcow.email/ is the ONLY exclusion I make for that. As it's an all in one docker managed solution. Where the only things you have to worry about is the reputation of your mailing IP.