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If the goal is space saving and a consistent visual quality rather than just having a library as AV1 for its own sake, I'd use ab-av1. Not sure how (or if) it'll handle the Opus audio channels cases, but bugs can be filed.
You can speed up the sampling process with --vmaf n_subsample=5, which in my experience works more accurately than either 2 or 4, possibly due to this bug/feature present in multiple encoders. You might also need to manually set the number of threads used for VMAF calculation with --vmaf n_threads=16, but YMMV.
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