nimpylib VS scikit-bio

Another nim & python thread that has not been mentioned yet here

https://news.ycombinator.com/item?id=28506531 - project allows creating pythonic bindings for your nim libraries pretty easily, which can be useful if you still want to write most of your toplevel code in python, but leverage nim's speed when it matters.

If you want to make your nim code even more "pythonic" there is a https://github.com/Yardanico/nimpylib, and for calling some python code from nim there is a https://github.com/yglukhov/nimpy

You make a fair point that using optimized numerical libraries instead of string methods will be ridiculously fast because they're compiled anyway. For example, scikit-bio does just this for their reverse complement operation [1]. However, they use an 8 bit representation since they need to be able to represent the extended IUPAC notation for ambiguous bases, which includes things like the character N for "aNy" nucleotide [2]. One could get creative with a 4 bit encoding and still end up saving space (assuming you don't care about the distinction between upper versus lowercase characters in your sequence [2]). Or, if you know in advance your sequence is unambiguous (unlikely in DNA sequencing-derived data) you could use the 2 bit encoding. When dealing with short nucleotide sequences, another approach is to encode the sequence as an integer. I would love to see a library—Python, Nim, or otherwise—that made using the most efficient encoding for a sequence transparent to the developer.

[1] https://github.com/biocore/scikit-bio/blob/b470a55a8dfd054ae...

[2] https://en.wikipedia.org/wiki/Nucleic_acid_notation

[3]