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Yes, your options are true. You can setup a Django backend (eg. https://www.django-rest-framework.org/) and a React app separately and just hit the backend in your requests. Or you can serve React files from your backend. Or a mix of the two. In terms of scalability you'll probably end up doing a hybrid of both. A good article about this: https://www.saaspegasus.com/guides/modern-javascript-for-django-developers/client-server-architectures/
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.