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I was trying, but i couldn't make GTK app working on Windows even after installing runtime environment , which i probably would include in app installer if it would work, so i decided to use AvaloniaUI, which seems to work out of box
Else, if you have Linux (not WSL2), I managed to compile a GUI app for it using Darling on Linux (tho it wasn't a GTK one). You can then probably use GTK by installing the GTK dev libs through Homebrew. As for the Rust part you'll need to download an older version of the Xcode command line tools from Apple's website (look at which macOS versions Darling & Xcode support, you'll need a free standard Apple account for that) and then you can install the Rust toolchain normally
(Assuming GTK4) For Windows you could try gtk4-cross. It was pretty clunky to use for Vala but since they have a Rust-specific image it should be easier for your use case