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Distributed Elixir can be done with Docker containers too, see https://github.com/bitwalker/libcluster which by default has some Kubernetes support but you can also have third party (or custom) clustering strategies. I've not done this myself but I've seen articles about this a lot during the past years.
Hot code updates for most applications aren't really worth it in my opinion, assuming you do something like blue/green rollover deployments. It's cool that it's possible though. But it requires appup files and afaik Distillery is one of the release tools that has support for it built-in.
Very cool.
I'm using Elixir to listen to change events via https://github.com/cpursley/walex (which I basically ripped off from Supabase).
Other replies are a bit outdated. It got a lot easier in OTP-23 to go without EPMD, https://blog.erlware.org/epmdlessless/ -- if you run with the same port. If not using the same port across nodes then you may want to look at epmdless https://github.com/tsloughter/epmdless