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Cython doesn't consume python3 type hints and needs special type hints of its own. But it's certainly more mature than other players in the field.
What we need is a rpython suitable for app programming and a stdlib written in that dialect.
https://github.com/py2many/py2many/blob/main/doc/langspec.md
If you're looking for a version of this which actually does what it promises including for multithreaded code and code that uses complex extensions, check out Nuitka. It is actively incredible.
> doesn't consume python3 type hints
Mypyc ships with mypy and does this. Mypy itself and Black are compiled with it, among other things.
The only project that compares 1:1 is Pythran: https://github.com/serge-sans-paille/pythran
Pythran is fairly nice, and it really does work. I tried it last year and it compiles down to modifiable templated C++. I was able to use it to build Python for a highly specialized environment.
All the others compile down to dynamically linked binaries, and that just puts them in the "other" box.